[Article updated on 19/09/2023]
Xenical is a pharmaceutical specialty based on orlistat. Used under medical supervision and combined with behavior change, a low-calorie diet and physical exercise, this medication, which is purchased at a reasonable price, can help obese people lose weight. The active ingredient reduces, without curbing the appetite, the absorption of fats and therefore energy intake. According to experts, it does this by inhibiting the enzymes that break down fats. The data available to date show that for some patients a reduction in body weight of up to ten percent is possible. Xenical, however, is known for its side effects, including fatty, greasy stools (steatorrhea). In Australia, the United States and the European Union, Xenical is available for sale without a prescription.
Before reading on
I’m not an expert in this field, but I am passionate about nutrition and health.
The articles you’ll find on my site are the result of in-depth research that I’d like to share with you. However, I would like to stress that I am not a health professional and that my advice should in no way replace that of a qualified physician. I’m here to guide you, but it’s important that you consult a professional for specific questions or medical concerns. Your well-being is important. So be sure to consult the appropriate experts and take the best possible care of yourself.
Price of Xenical
Indication and price
Xenical is indicated for the treatment of obesity, a medical condition in which excess body fat accumulates to the point of having a negative effect on health. Obesity increases the likelihood of various diseases, particularly cardiovascular disease, type 2 diabetes, obstructive sleep apnea, certain types of cancers, osteoarthritis and depression. According to doctors, obesity is most often caused by excessive food consumption, lack of physical activity and genetic predisposition. A few cases are primarily caused by genes, endocrine disorders, medications, or mental disorders.
This medicine should only be used by patients with a body mass index (BMI) of 30 kg/m² or more. However, Xenical can be prescribed to patients with a BMI of 27 kg/m², but who have other risk factors such as hypertension, type 2 diabetes or high cholesterol levels. BMI is not a direct measure of fat and its guidelines do not apply to athletes and pregnant women. BMI is calculated by dividing the patient’s body weight in kilograms by the square of their height in meters.
Xenical may also be used in combination with diabetes medications to improve blood sugar control in people who are overweight or obese and have type 2 diabetes.
How Xenical works
According to experts, orlistat is a statin that inhibits fat-digesting enzymes (lipases) in the gastrointestinal tract. The active ingredient binds covalently to the active site hydroxyl group on pancreatic and gastric lipases and forms a stable complex with them. This results in a conformational change in the enzyme which causes exposure of the active catalytic site. When the active site is exposed, the hydroxyl group located on the serum residue is acylated. This leads to irreversible inactivation of the enzyme. Inactive lipase is unable to hydrolyze fats into absorbable fatty acids and monoglycerides, therefore triglycerides are excreted undigested through feces
Normally, fats from the diet are broken down by enzymes in the stomach and intestines and are then absorbed into the body for storage. Orlistat stops these enzymes from working, meaning less than 30-40% of dietary fat will be absorbed, I talk about this in my article on Orlistat. Instead, unabsorbed fat will pass directly into the stool. The therapeutic effect begins in the stomach and continues to the upper region of the small intestine. Lipases are enzymes needed to break down dietary fat into fatty acids, which are the form of fat that can be absorbed through the intestinal wall. Chemically, the active ingredient in Xenical binds covalently to the active site of gastric and pancreatic lipases.
Dietary fats come in the form of triglycerides, free fatty acids and monoglycerides. As a result, 35% of fats consumed are not absorbed, thereby lowering serum cholesterol levels. This leads to a reduction in body weight, which may improve glucose tolerance, secondary blood pressure, and metabolic syndrome. However, the orlistat in Xenical appears to be counterproductive for stimulating appetite. Studies have shown that the drug is only very partially absorbed by the body. Plasma concentrations of unmetabolized orlistat are not measurable eight hours after oral ingestion of the drug.
FAT CAPTURE WITH XENICAL
- Clinically proven efficacy
- Easy-to-follow treatment
For people who prefer a video format, I made a short 3-minute video that presents Xenical and how it works. It’s right here! :
How to use Xenical?
People who purchase the product over the counter for self-treatment should read all instructions on the product package before taking this medication. According to doctors, Xenical capsules are taken 1 hour after a meal, usually 3 times a day. In all cases, this medication should be taken as directed by the doctor. For adults and children over 12 years old, the dosage is 120 mg in 3 doses. This low-cost medication is not intended for patients under 12 years of age. If the patient misses a meal, he or she will need to skip that dose of the medication. To avoid the risk of unpleasant side effects, no more than 30% of calories from food should come from fat.
Do not increase the recommended dose or use this medication for longer than prescribed by your doctor. Increasing doses will not speed up effectiveness, and the risk of side effects may increase. This inexpensive medication may interfere with the absorption of certain fat-soluble vitamins, including vitamins A, D, E, and K. To do this, a daily multivitamin supplement containing these nutrients is recommended for patients treated with Xenical. The multivitamin complex should be taken at least 2 hours before or 2 hours after taking orlistat. A good idea would be to take it at bedtime.
Patients who are taking cyclosporine should take this medication at least 3 hours before or after to ensure that the full dose of cyclosporine is absorbed into the bloodstream. Those who take levothyroxine should do so at least 4 hours before or after taking Xenical. Significant weight loss should be observed within 2 weeks of starting treatment with Xenical. If the patient’s condition does not improve after 12 weeks, the treatment must be stopped and medical advice sought. If it worsens, you will need to consult a doctor.
Taking this medication alone is not enough to induce satisfactory weight loss. Xenical should be taken with a rich, well-balanced diet. The patient must control the number of calories he ingests and must establish a physical exercise program with his doctor. If you forget, take the medicine as soon as you remember within an hour after your last meal. However, you should not take a double dose. If you forget several doses, you should inform your doctor and follow the advice he will give. You should not change the prescribed dose yourself, unless your doctor asks you to do so. Patients who have further questions on the use of this medication should contact their doctor or pharmacist.
According to experts, you should try to limit the number of food calories to around 500 calories per day. This should result in a loss of 0.5 kg per week. You will also need to take care to eat slowly and enjoy the food, without rushing. Doing physical exercises regularly will improve results.
Where to buy Xenical?
In many European countries, and in particular France, Xenical is a medicine requiring medical prescription. This means that it is only accessible to patients who have visited a doctor’s office and to whom the doctor has issued a prescription. To buy it in a physical pharmacy, you would therefore have to have visited a doctor, which is not easy when you know how shameful this pathology is.
Fortunately, there is a trick to having this medication delivered to you without having to be examined thoroughly by a doctor. The idea would be to buy it from an online pharmacy approved by the European Medicines Agency. To do this, simply go to the website of this pharmacy and make an online consultation. After answering a questionnaire, the patient is issued with a purchasing authorization with which he can then purchase the medicine on the site. Delivery can be made to a relay point or to the patient’s home. The purchased medicine is generally delivered within 48 hours maximum depending on its geographical location.
However, you must take care to only contact approved pharmacies. Indeed, the popularity of Xenical has favored the proliferation of counterfeits which are sold secretly by unscrupulous people. Far from containing orlistat, these copies instead contain compounds harmful to the user’s health. In the opinion of experts, these products are generally sold at very low prices, but one must absolutely avoid compromising one’s health by opting for their purchase.
FAT CAPTURE WITH XENICAL
- Clinically proven efficacy
- Easy-to-follow treatment
Side effects and delivery
The most common side effects (1 in 10 users) include headache, abdominal pain, urgent or increased need to relieve yourself, and flatulence. We also have fatty, oily or watery stools as well as lowered blood sugar levels in some people with type 2 diabetes. Common side effects (1 to 10 users in 100) include rectal pain or discomfort, loose stools, fecal incontinence, bloating, as well as oral and dental problems. Allergic reactions have also been observed, manifested by itching, rash, slightly raised papules, severe difficulty breathing, nausea and vomiting.
According to specialists, increases in the levels of certain liver enzymes can be observed. Some patients may have hepatitis (inflammation of the liver) with symptoms that may include yellowing of the skin and eyes, itching, dark urine, stomach pain, and loss of appetite. Others may be prone to pancreatitis (inflammation of the pancreas). Xenical should be discontinued if such symptoms occur and the treating physician should be informed. cases of gallstones have also been reported.
Patients experiencing hives, rash, or itching all over the body should contact a doctor immediately. The same is true for those who experience difficulty breathing or swallowing, severe or continuous stomach pain, as well as excessive fatigue or generalized weakness. Patients experiencing nausea, vomiting and loss of appetite should observe this same precaution. This same precaution should be observed in case of pain in the upper right part of the stomach, yellowing of the skin or eyes, dark urine or light stools.
Researchers recently discovered that orlistat can inhibit an enzyme involved in the proliferation of cancer cells. However, potential side effects of Orlistat, such as inhibition of other cellular targets or low bioavailability, could hinder its application as an effective anti-tumor agent. A profiling study undertook an approach to search for novel cellular targets of orlistat.
The anticoagulant effect of warfarin (Coumadin, Jantoven) depends on the amount of vitamin K in the body, and vitamin K is one of the vitamins that binds to fat. Patients receiving warfarin and starting treatment with orlistat should have their blood clotting checked regularly. Indeed, the interaction between these two drugs can increase the effects of warfarin and lead to abnormal bleeding.
Orlistat may reduce the absorption and blood levels of cyclosporine (Sandimmune) when the two drugs are given together. Therefore, cyclosporine should be administered two hours before or after, and more frequent monitoring of cyclosporine levels may be necessary. Hypothyroidism has been reported when orlistat and levothyroxine (Synthroid, Levoxyl, Levothroid, Unithroid) are combined. Patients treated with both orlistat and levothyroxine should be monitored for changes in thyroid function. Orlistat and levothyroxine should be taken at least four hours apart.
The use of orlistat is contraindicated in patients with chronic malabsorption syndrome or cholestasis. Organic causes of obesity, such as hypothyroidism, should be excluded before prescribing orlistat. Gastrointestinal effects may, in fact, increase when orlistat is taken. Xenical may reduce the absorption of certain fat-soluble vitamins and beta-carotenes. Additionally, vitamin D and beta-carotene levels may be low in obese patients. To ensure adequate nutrition, multivitamin supplementation is recommended. The supplement should be taken at least two hours before or after administering orlistat.
Elevated urinary oxalate levels may occur in some patients treated with Xenical. Cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported. In patients at risk of renal insufficiency, monitoring of renal function is recommended. Caution should be used when prescribing this medication to patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis. Improved diabetes control may enhance the weight loss that Xenical can provide. A reduction in doses of hypoglycemic agents or insulin may be necessary. There is an increased risk of cholelithiasis in the event of significant weight loss.
Pregnancy and breast feeding
Data on the use of orlistat during pregnancy do not suggest an increased risk of fetal birth defects. There are no data on spontaneous abortion, intrauterine death, premature delivery, low birth weight, or neonatal complications to assess risk. As orlistat may impair the absorption of fat-soluble vitamins (A, D, E and K). Routine use during pregnancy is therefore not recommended. Maternal obesity is associated with an increased risk of birth defects and adverse outcomes for the mother and fetus. Pregnant women with a BMI above 30 are advised to take folic acid supplementation from one month before conception until the end of the first trimester. Dieting or using weight loss products during pregnancy is not recommended.
Studies on the use of orlistat during pregnancy are limited. After the first trimester, a detailed analysis of fetal abnormalities should be considered in addition to any other prenatal examination. Women and healthcare professionals should be aware that prenatal detection of fetal abnormalities is compromised by increasing BMI and that a normal scan is not informative with respect to results. Other risk factors that independently increase the risk of adverse pregnancy outcomes. Clinicians are reminded that it is important to consider these factors when assessing case-specific risks.
Xenical and risks of liver damage
In 2009, the US drug agency FDA issued an alert regarding orlistat, the active ingredient in Xenical. The agency warned patients of a risk of liver damage linked to taking Xenical. One of these cases is rather telling. A 54-year-old African American woman with high blood pressure developed liver failure. She had noticed increasing fatigue, jaundice and confusion. She drank little alcohol and refused tobacco or illicit drug use, but she had been taking over-the-counter orlistat for two months. Physical examination revealed scleral jaundice and slow speech.
Laboratory tests showed abnormal liver function coupled with coagulopathy. Viral and acute autoimmune serologies were negative, as was the toxicological analysis. Liver biopsy showed necrotic liver parenchyma probably secondary to drug toxicity. Based on his clinical presentation and time course, the pattern of liver injury observed on a liver biopsy, and the lack of another plausible explanation, his liver failure was most likely associated with the use of the orlistat.
His condition continued to deteriorate and eventually underwent an orthotopic liver transplant. Fourteen cases of severe liver injury associated with orlistat use have been reported, four of which are detailed in the literature. This is the second case of liver failure associated with orlistat use that has been published. Clinicians should be aware of the increasing number of cases of liver injury associated with orlistat use and monitor their patients carefully.
Xenical is one of the most sought-after drugs for the treatment of obesity, which in just a few years has turned into a global pandemic. It is not a miracle cure, but it must be combined with a lifestyle change to be effective. It actually helps with weight loss, because eating less and moving more are the most effective techniques for getting rid of excess weight. Most side effects of Xenical are bothersome (watery, oily stools), but some can be fatal.
My opinion in detail
My overall rating: 2.6/5
In my reflection I take into account various elements to evaluate the product, in the case of a fat sensor, I took into account several criteria to determine its overall effectiveness:
- Composition: in particular, it is important to take into account the micronutrients and macronutrients which play an essential role in weight loss and maintaining good health,
- Notoriety: it is an important criterion, because it inspires confidence and meets consumer expectations,
- The feeling of satiety: it also plays a crucial role in feeling energetic and avoiding cravings,
- The price: it must be affordable in order to be able to use the meal replacement regularly,
- The dosage: it must be practical and without constraints, thus facilitating taking the daily dose.
Orlistat is a medicine used to treat obesity. It inhibits an enzyme called pancreatic lipase to reduce the body’s absorption of dietary fat. It is composed mainly of orlistat, without stimulants or amphetamines. Orlistat is not a natural product, it is a medicine! This is why I only gave 3.5 for the composition
The brand behind Xenical is Roche, a Swiss pharmaceutical company. Roche markets Xenical in many countries as a treatment for obesity. However, this brand is not necessarily recognized by the general public.
The price: 1.5/5
The price of Xenical is difficult to afford. As a result, a box costs more than €161 for 84 capsules. Where the capsule costs around €0.15 per unit, a Xenical capsule costs around €1.92. For me, this makes accessibility really, really restricted.
What do users think of the effectiveness of Xenical?
Xenical is not effective for everyone and is by no means a miracle weight loss pill. Orlistat is recommended if the patient is overweight and previous weight reduction efforts have not worked. As long as the latter follows a reasonable, balanced diet combined with regular physical exercise, he will have a good chance of losing weight.
In clinical trial data, the average weight loss was 50% more compared to the control group. This means that if the patient can lose 6 kg with diet alone, they could lose up to 9 kg by combining orlistat. Additionally, those who took Orlistat were shown to maintain greater weight loss than the placebo group. For maximum effectiveness of Xenical, one capsule should be taken with each main meal, with a maximum of three capsules per day beforehand. In the opinion of nutritionists, if the patient misses a meal or the meal does not contain fat, he does not need to take the capsule.
FAT CAPTURE WITH XENICAL
- Clinically proven efficacy
- Easy-to-follow treatment
Xenical is a medicine used to treat obesity, so it is not open to everyone. Its composition is not natural, mainly based on orlistat, reduces fat absorption. However, its high price and limited awareness may pose challenges in terms of accessibility to purchasing this product, although it has proven its effectiveness.
Attention : this medication is available without a prescription but I advise you to seek professional advice before taking this medication which is not without significant side effects.
Not really accessible, not very well known, Xenical has alternatives that can meet these requests! Here they are just below with my detailed opinion: